Paracetamol can cause Asthma  , Several studies have noted a dose-dependent relationship between the regular use of paracetamol and the risk of developing allergic disease in general and asthma in particular.The effect has been noted in both adults and in offspring of mothers taking regular paracetamol during pregnancy.Paracetamol use has been postulated to be a risk for asthma because it induces depletion of the antioxidant glutathione in lung tissue. As a result, oxidative damage occurs, prostaglandin E2 production increases, and Th2 processes are promoted.

Cockroach allergen — in studies of inner city asthma, sensitization to cockroach allergen has been shown to be a significant risk factor in the development of asthma.

In addition, morbidity from asthma in inner-city children is associated with the presence of cockroach allergy and exposure to high levels of cockroach allergen in bedroom dust.



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